Nickel-catalysed deaminative Sonogashira guhuza umunyu wa alkylpyridinium ushobojwe na NN2 pincer ligand

Alkynes iboneka cyane mubicuruzwa bisanzwe, molekile ikora mubinyabuzima nibikoresho bikora.Muri icyo gihe, ni n’umuhuza wingenzi muri synthesis organique kandi birashobora guhinduka muburyo bwo guhindura imiti.Kubwibyo, iterambere ryuburyo bworoshye kandi bunoze bwubaka alkynes bwihutirwa kandi burakenewe.Nubwo Sonogashira reaction yatangijwe nicyuma cyinzibacyuho nimwe muburyo bwiza kandi bworoshye bwo guhuza aryl cyangwa alkenyl yasimbuwe na alkynes, reaction yo guhuza irimo amashanyarazi ya alkyl idakorwa biterwa no gukuraho kuruhande nko kurandura bH.Haracyari ibibazo byinshi hamwe nubushakashatsi buke, ahanini bugarukira kubidukikije bitangiza ibidukikije kandi bihenze bya alkogène.Kubwibyo, ubushakashatsi niterambere ryibisubizo bya Sonogashira bya reagent nshya, zidahenze kandi byoroshye kuboneka alkylation reagent bizaba bifite akamaro kanini haba muri laboratoire no mubikorwa byinganda.Iri tsinda ryateguye ubuhanga kandi ryateje imbere uburyo bushya, bworoshye kuboneka kandi buhamye hagati ya NN2 pincer ligand yo mu bwoko bwa NN2, ku nshuro yayo ya mbere yatahuye neza kandi ihanitse ikomoka kuri alkylamine ikomoka kuri alkinine hamwe na alkynes ya terminal hamwe nisoko ryinshi rya catalitiki ya nikel, bihendutse kandi byoroshye kuri kubona.Ihuriro ryambukiranya imipaka ryakoreshejwe neza muguhindura gutinda no guhindura alkynylation yibicuruzwa bisanzwe hamwe na molekile yibiyobyabwenge, ibyo bikaba byerekana imikorere myiza yimikorere hamwe nitsinda rihuza imikorere, kandi bitanga udushya kuri synthesis ya alkine ikomeye yasimbuwe.Nuburyo bufatika.